💊 9 Weight-Loss & Diabetes Medications Compared (October 2026)

Prescription medicines for weight management and type 2 diabetes. Information only. Open any item to see its alternatives.

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General information, not medical advice.Contrave and the options below are prescription medicines. Only a licensed clinician who knows your health history can say which is right for you. Never start, stop or switch treatment without medical advice.

Contrave

Naltrexone-bupropion tablets approved for chronic weight management

Daily pillFDA-approved for weight management

8 alternatives to Contrave →

Prescription

Mounjaro

Weekly tirzepatide injection approved for type 2 diabetes

Approved for type 2 diabetesGLP-1 medicineWeekly injection

8 alternatives to Mounjaro →

Prescription

Orlistat (Xenical / Alli)

Fat-absorption blocker taken with meals; prescription Xenical and lower-dose over-the-counter Alli

Daily pillFDA-approved for weight managementOver-the-counter version

8 alternatives to Orlistat (Xenical / Alli) →

Over the counter

Ozempic

Weekly semaglutide injection approved by the FDA for type 2 diabetes

Not FDA-approved for weight loss; Wegovy is the weight-management version of semaglutide

Approved for type 2 diabetesGLP-1 medicineWeekly injection

8 alternatives to Ozempic →

Prescription

Qsymia

Phentermine-topiramate extended-release capsules approved for chronic weight management

Daily pillFDA-approved for weight management

8 alternatives to Qsymia →

Prescription

Rybelsus

Daily semaglutide tablet approved for type 2 diabetes

Approved for type 2 diabetesDaily pillGLP-1 medicine

8 alternatives to Rybelsus →

Prescription

Saxenda

Daily liraglutide injection approved for chronic weight management

Daily injectionFDA-approved for weight managementGLP-1 medicine

8 alternatives to Saxenda →

Prescription

Wegovy

Weekly semaglutide injection approved for chronic weight management

FDA-approved for weight managementGLP-1 medicineWeekly injection

8 alternatives to Wegovy →

Prescription

Zepbound

Weekly tirzepatide injection approved for chronic weight management and for moderate to severe obstructive sleep apnea in adults with obesity

FDA-approved for weight managementGLP-1 medicineWeekly injection

8 alternatives to Zepbound →

Prescription

Frequently asked questions

How many weight-loss & diabetes medications do you compare?

This page compares 9 weight-loss & diabetes medications, including Contrave, Mounjaro, Orlistat (Xenical / Alli), Ozempic, Qsymia.

Which weight-loss & diabetes medications do people look for alternatives to most?

On our site the most searched are Ozempic.

Which weight-loss & diabetes medications are FDA-approved for weight management?

Contrave, Orlistat (Xenical / Alli), Qsymia, Saxenda, Wegovy, Zepbound.

Which weight-loss & diabetes medications are GLP-1 medicines?

Mounjaro, Ozempic, Rybelsus, Saxenda, Wegovy, Zepbound.

Which weight-loss & diabetes medications are daily pills?

Contrave, Orlistat (Xenical / Alli), Qsymia, Rybelsus.

Which weight-loss & diabetes medications are weekly injections?

Mounjaro, Ozempic, Wegovy, Zepbound.

How do I find an alternative to one of these?

Open any item to see its ranked alternatives. For example, our Ozempic alternatives page lists 8 options, and each of those links to its own list.

Is this medical advice?

No. These pages are general information only. Talk to a licensed clinician before starting, stopping or switching any treatment.

When was this page last updated?

The data on this page was last reviewed on October 19, 2026. Prices for software are checked automatically where possible.

How are weight-loss & diabetes medications ordered on this page?

Items are listed alphabetically. Open any item to see alternatives ranked by how closely they match it.

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