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Contrave Alternatives: 8 Options Compared (2026)

Contrave: naltrexone-bupropion tablets approved for chronic weight management. Here are 8 alternatives. Orlistat (Xenical / Alli) is the closest match, sharing 100% of Contrave's tracked attributes. Every option links to its own alternatives, so you can keep exploring.

Last reviewed October 19, 2026 · 8 alternatives

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General information, not medical advice.Contrave and the options below are prescription medicines. Only a licensed clinician who knows your health history can say which is right for you. Never start, stop or switch treatment without medical advice.
Q
#2 · 100% match

Qsymia

Phentermine-topiramate extended-release capsules approved for chronic weight management
✓ Daily pill✓ FDA-approved for weight management
8 alternatives to Qsymia →
Prescription
O
#3

Ozempic

Weekly semaglutide injection approved by the FDA for type 2 diabetes
Not FDA-approved for weight loss; Wegovy is the weight-management version of semaglutide
+ Approved for type 2 diabetes+ GLP-1 medicine+ Weekly injection
8 alternatives to Ozempic →
Prescription
S
#5 · 50% match

Saxenda

Daily liraglutide injection approved for chronic weight management
✓ FDA-approved for weight management + Daily injection+ GLP-1 medicine
8 alternatives to Saxenda →
Prescription
W
#6 · 50% match

Wegovy

Weekly semaglutide injection approved for chronic weight management
✓ FDA-approved for weight management + GLP-1 medicine+ Weekly injection
8 alternatives to Wegovy →
Prescription
Z
#7 · 50% match

Zepbound

Weekly tirzepatide injection approved for chronic weight management and for moderate to severe obstructive sleep apnea in adults with obesity
✓ FDA-approved for weight management + GLP-1 medicine+ Weekly injection
8 alternatives to Zepbound →
Prescription

Keep exploring

Alternatives to the alternatives — each link opens its own list.

OOrlistat (Xenical / Alli) alternatives

QQsymia alternatives

OOzempic alternatives

RRybelsus alternatives

SSaxenda alternatives

WWegovy alternatives

Contrave alternatives: FAQs

What is Contrave?

Naltrexone-bupropion tablets approved for chronic weight management. It is listed in our Weight-Loss & Diabetes Medications category.

What are the best alternatives to Contrave?

The top options in our list are Orlistat (Xenical / Alli), Qsymia, Ozempic, Rybelsus and Saxenda. Which one suits you depends on your health history, so discuss it with a licensed clinician.

Do I need a prescription for Contrave?

Contrave is a prescription medicine, so it needs a prescription from a licensed clinician.

Which alternative is most similar to Contrave?

Orlistat (Xenical / Alli) is the closest match, sharing 100% of Contrave's tracked attributes.

What are the key facts about Contrave?

Based on our data, Contrave offers or is known for: Daily pill, FDA-approved for weight management.

Which Contrave alternatives are GLP-1 medicines?

Ozempic, Rybelsus, Saxenda, Wegovy, Zepbound and Mounjaro.

Which Contrave alternatives are weekly injections?

Ozempic, Wegovy, Zepbound and Mounjaro.

Which Contrave alternatives are daily pills?

Orlistat (Xenical / Alli), Qsymia and Rybelsus.

Which Contrave alternatives are FDA-approved for weight management?

Orlistat (Xenical / Alli), Qsymia, Saxenda, Wegovy and Zepbound.

Can I switch from Contrave on my own?

No. Prescription medicines should only be started, stopped or switched under the guidance of a licensed clinician.

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